Cri du chat syndrome.

Since the description of the first three cases of the 'cri du chat' syndrome by Lejeune, Lafourcade, Berger, Vialatte, Boeswillwald, Seringe, and Turpin (1963), 12 patients have been reported on in whom part of the short arms of a chromosome in the 4-5 group were absent (Lejeune, Lafourcade, de Grouchy, and Berger, 1964b; Punnett, Carpenter, and DiGeorge, 1964; Book, Atkins, and Santesson, 1963; de Grouchy, Arthuis, Salmon, Lamy, and Thieffry, 1964; Dumars, Gaskill, and Kitzmiller, 1964; Macintyre, Staples, LaPolla, and Hempel, 1964; McCracken and Gordon, 1965; Hijmans and Shearin, 1965; Dyggve and Mikkelsen, 1965). The clinical features have all been similar; with characteristic cry, severe mental retardation, microcephaly, moon face, hypertelorism, epicanthus, antimongoloid slant of palpebral fissures, low-set ears, and abnormal dermatoglyphics.